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本片讲述了一个怪诞而充满谐趣的故事。乔伊斯有点不善交际，她在小城镇的酒店里当接待员，好好的日子却突然遭到意外，一位粗心的工人竟然把一根钉子射进她的脑子，钉子正好压迫了她的某根神经，让她得了一种怪病，从此“欲”壑难填，然而不善交际的她不得不通过社交，以满足自己强烈的性欲，最后无奈乔伊斯收起行囊，决定去华盛顿州进行治疗。在纽约，她遇见了表面上年轻放荡、实则满腹阴谋的国会议员（杰克·吉伦哈尔饰），议员得知她的怪病后，利用她的美貌和性欲，当成政治资本，从中获得利益，一系列的阴谋从此开始，单纯的乔伊斯能否走出阴谋、治愈怪病？。Newly elected president Judson Hammond is shown to be a lackey of his party, willing to follow the party line even if it's not in the best interest of the people. Showing off by driving his own car to a political meeting, he crashes at high speed. Comatose, he is not expected to recover. But on regaining consciousness, he is a changed man. Dismissing his cabinet and defying Con...。